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KMID : 0903520090520040375
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2009 Volume.52 No. 4 p.375 ~ p.379
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Antitumor Components Isolated from the Heartwood Extract of Dalbergia odorifera
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Choi Chun-Whan
Choi Yeon-Hee
Cha Mi-Ran
Kim Young-Sup
Yon Gyu-Hwan
Kim Young-Kyoon
Choi Sang-Un
Kim Young-Ho
Ryu Shi-Yong
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Abstract
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Ongoing search for promising antitumor components from plant resources, we found that the methanol extract from the heartwood of Dalbergia odorifera (Leguminosae) demonstrated a significant inhibition on the proliferation of human tumor cell lines including multidrug resistant cells in vitro. Intensive bioassay-guided purification of the extract finally led to the isolation of seven flavonoids and two phenolic components as active constituents for antitumor property, in vitro, i.e., medicarpin (1), 2-hydroxy-3,4-dimethoxybenzaldehyde (2), formononetin (3), tectorigenin (4), mucronulatol (5), (3R)-5\’-methoxyvestitol (6), hydroxyobtustyrene (7), liquiritigenin (8), and (3R)- calussequinone (9), respectively.
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KEYWORD
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antitumor, Dalbergia odorifera, flavonoid, Leguminosae, multidrug resistant cells
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